Which enzyme is sensitive to liver obstruction?

Which enzyme is sensitive to liver obstruction?

• A. AST
• B. ALT
• C. GGT
• D. Amylase

Answer: (C)

The enzyme that is sensitive to liver obstruction is gamma-glutamyl transferase (GGT). GGT is primarily found in the liver, and its levels can increase in response to liver conditions such as biliary obstruction or cholestasis. When there is a blockage in the bile ducts, the levels of GGT in the blood elevate, making it a useful marker for liver dysfunction related to obstruction.

In contrast, while aspartate aminotransferase (AST) and alanine aminotransferase (ALT) are enzymes also associated with liver function, they are more specifically indicators of liver cell injury rather than obstruction. Amylase, on the other hand, is primarily linked to pancreatic function and may rise in conditions affecting the pancreas, but it does not specifically indicate liver obstruction. Thus, GGT is regarded as the enzyme most sensitive to liver obstruction due to its close association with the biliary system and liver health.